Galen eCalcs - Calculator: FRAX WHO Fracture Risk

About FRAX

FRAX® is a sophisticated risk assessment instrument, developed by the University of Sheffield in association with the World Health Organization. It uses risk factors in addition to DXA measurements for improved fracture risk estimation. It is a useful tool to aid clinical decision making about the use of pharmacologic therapies in patients with low bone mass. The International Osteoporosis Foundation supports the maintenance and development of FRAX®.

Calculator Inputs

Input	Mapping Type	Description
Ethnicity	Demographics	Patient Ethnicity
Sex	Demographics	Patient Sex
Age	Demographics	Patient Age
Weight	Vitals	Patient’s Weight
Height	Vitals	Patient’s Height
Previous Fracture	Problems / No Default Mappings	A previous fracture in adult life occurring spontaneously, or a fracture arising from trauma which, in a healthy individual, would not have resulted in a fracture
Parental Hip Fracture	Manual Input	History of hip fracture in the patient’s mother or father
Smoking Status	Problems	Patient’s smoking status
Glucocorticoids	Medications	Patient is currently exposed to oral glucocorticoids or has been exposed to oral glucocorticoids for more than 3 months at a dose of prednisolone of 5mg daily or more (or equivalent doses of other glucocorticoids)
Rheumatoid Arthritis	Problems	Patient has a confirmed diagnosis of rheumatoid arthritis
Secondary Osteoporosis	Problems	Patient has a disorder strongly associated with osteoporosis. These include type 1 (insulin dependent) diabetes, osteoporosis imperfect in adults, untreated long-standing hyperthyroidism or premature menopause (less than 45 years old), chronic malnutrition or malabsorption and chronic liver disease
Alcohol (3+ Per Day)	Problems / No Default Mappings	Patient takes 3 or more units of alcohol daily. A unit of alcohol varies slightly in different counties from 8-10g of alcohol. This is equivalent to a standard glass of beer (285ml), a single measure of spirits (30ml), a medium-sized glass of wine (120ml), or a 1 measure of an aperitif (60ml)
Femoral Neck BMD	Results	Femoral neck bone mineral density in g/cm^2 Ventricular Hypertrophy || Results || Whether the patient has left ventricular hypertrophy

Calculator Outputs

Output	Mapping Type	Description
Major Osteoporotic Fracture	Result	Ten year probability of major osteoporotic fracture
Hip Fracture	Result	Ten year probability of hip fracture
T-Score	Result	Bone density at femoral neck when compared to the young normal reference mean

References

http://www.shef.ac.uk/FRAX/tool.aspx